By Aaron Summers () |
July 19, 2011, 5:30 pm
Bristol-Myers Squibb may have already created the first birth control pill for men. The drug, BMS-189453, was developed ten years ago by BMS. Initial tests on rat subjects, reported in October of 2000 in the Oxford Journal of Toxicological Science, showed that the drug was ‘toxic’ to the animals’ testicles. Based on this effect, the company decided not to continue developing the compound.
A report release, explaining this decision, was seen by Dr. Debra J. Wolgemuth, Ph.D. a professor and researcher at Columbia University Medical Center. Dr. Wolgemuth said that she was “intrigued,” and that “One company’s toxin may be another person’s contraceptive. She proceeded, with her team, to test the drug on mice at lower doses to see if the drug’s effects weren’t permanent. A four week-dosing cycle at 1.0mg/kg of the test subject’s body weight showed that the sterility caused by the drug was reversible.
The most promising aspect of this new drug is that it may control reproduction while bypassing hormonal-based treatments. Such methods have, in the past, produced unwanted side-effects: higher risk for cardiovascular diseases, benign prostatic hyperplasia, ethnically diverse levels of efficiency, and a diminished sex-drive (one thinks of The Gift of the Magi). Dr. Chung, a research assistant working with Dr. Wolgemuth has stated that “an additional benefit of our compound is that it can be taken orally as a pill, avoiding the injection process. It also appears to have a very rapid effect on sperm production, and an even more rapid recovery when fertility is desired.” Continue Reading »